“Advancing Precision Medicine and Precision Health with CMOS-enabled Continuous Monitoring of Molecules, Cells, and Beyond”
Thursday, March 26 @ 1:00 pm
Abstract
Continuous monitoring of specific biomarkers at real time, as opposed to the current standard end-point assay, introduces a new dimension in medicine and healthcare by offering longitudinal information. Such a scheme enables faster and evidence-based decision making in medical treatments as well as early disease detection to improve quality-of-life. In this talk, I will present my research on various biomedical systems for continuous monitoring at different levels with emerging applications including in vivo drug monitoring for personalized pharmacokinetics characterization and biophysical-based circulating tumor cells quantification. In particular, my research harvests the power of CMOS integrated circuits, applied physics, and advanced biotechnology to address biosensing requirements on sensitivity, specificity, throughput, multiplexing, device miniaturization, and system scaling. In this talk, I will present four systems: (1) an electrochemical-sensing implant with wireless powering and telemetry for in vivo molecular monitoring using reagentless structure-switching aptamers; (2) a cytometry-on-CMOS system exploiting injection-locking mechanism for large-scale single-cell dielectric spectroscopy study at microwave frequencies; (3) a frequency-multiplexed neural-recording architecture with distributed “oscillatrodes’” for ultra-high-density neural probe; and (4) new sensing physics for fingertip heart-rate monitoring at a reduced power consumption. I will also present my research on broadband wireless circuits and systems for communication and imaging.
Biography
Jun-Chau Chien received the B.S. and M.S. degrees from National Taiwan University in 2004 and 2006, and Ph.D. degree from University of California, Berkeley, in 2015. After 2-year postdoctoral training, he is now a Staff Research Engineer at Electrical Engineering Department, Stanford University. He also held industrial positions at Xilinx, InvenSense, and HMicro in 2012, 2015, and 2017, respectively. His research focuses on in vivo and in vitro integrated biosensors coupling CMOS with molecular engineering, RF/millimeter-wave/sub-THz integrated circuits, and on-chip precision measurement techniques.
He was the recipient of the 2019 CICC Outstanding Regular Paper Award, the 2014 Microwave Theory and Techniques Society (MTT-S) Graduate Fellowship for Medical Applications, the 2014 Solid-State Circuit Society (SSCS) Predoctoral Achievement Award, the 2013–2014 Outstanding Graduate Student Instructor Award of the University of California at Berkeley, the 2014 Analog Devices Outstanding Design Award, the 2008 Berkeley Wireless Research Center Fellowship, the 2007 International Solid-State Circuits Conference (ISSCC) Silk Road Award, and the 2006 Outstanding Research Award and Annual Best Thesis Award of the Graduate Institute of Electronics Engineering, National Taiwan University, Taipei, Taiwan. He was a co-recipient of the 2010 ISSCC Jack Kilby Award for Outstanding Student Paper for his work on a 90 GHz pulser with 30 GHz of bandwidth for medical imaging.